Scientist - Endometrial Biology
AI Summary
Leads research to understand molecular and cellular mechanisms of implantation and peri-implantation development using advanced endometrial model systems.
About this role
About us
Role overview
What you'll do:
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Develop endometrial model systems: Establish, optimize, and maintain in vitro endometrial models, including primary cells, organoids, or engineered tissue systems that recapitulate peri-implantation physiology.
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Investigate implantation mechanisms: Design and execute experiments to identify molecular pathways regulating embryo attachment, invasion, decidualization, and early maternal-fetal signaling.
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Characterize cellular and molecular responses: Apply imaging, histology, transcriptomics, and molecular assays to evaluate endometrial receptivity, cellular differentiation, and tissue remodeling.
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Define embryo–endometrium interactions: Develop assays to study signaling and structural interactions during implantation and early development, integrating biological findings into experimental platform design.
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Integrate multi-modal datasets: Analyze and interpret molecular, imaging, and functional data to generate mechanistic insight and guide experimental iteration.
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Collaborate across disciplines: Partner with embryology, bioengineering, and computational teams to translate biological findings into design requirements for experimental systems supporting early development.
Core requirements:
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PhD in Reproductive Biology, Developmental Biology, Cell Biology, Molecular Biology, or a related field, or 5+ years of relevant academic or industry experience.
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Demonstrated expertise in endometrial biology, implantation biology, or maternal–fetal interface research.
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Hands-on experience with mammalian cell culture and endometrial model systems (primary cells, stromal/epithelial co-culture, or organoids).
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Strong understanding of decidualization, endometrial receptivity, and peri-implantation developmental processes.
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Experience designing and executing mechanistic biological experiments independently.
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Excellent organizational skills and attention to experimental rigor.
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Ability to work collaboratively in an interdisciplinary research environment.
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Enthusiasm for mission-driven science within a fast-paced startup setting.
You'll stand out with:
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Experience working with human endometrial organoids or advanced in vitro implantation models.
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Expertise in hormone-responsive endometrial systems and decidualization assays.
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Hands-on histology experience, including tissue processing, sectioning, staining, and microscopy-based analysis.
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Experience with transcriptomics, single-cell sequencing, or spatial omics approaches.
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Background studying embryo–maternal signaling pathways or early placentation.
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Experience integrating molecular datasets with functional developmental outcomes.
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Prior startup, translational research, or early-stage technology development experience.
Why e184?
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Unrivaled impact: Your work directly enables technology that transforms human fertility and reproductive medicine.
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Full-spectrum growth: Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.
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Best of both worlds: Experience the creative chaos of an early-stage startup with the stability of a well-capitalized company.
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Elite collaboration: Work alongside a world-class team who are as driven as you are.
The perks:
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Competitive salary + equity participation is considered
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State-of-the-art facility in Portland metro area
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Comprehensive Medical, Dental, Vision, and 401(k) with company match
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20 days PTO + 11 paid holidays
Skills
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