Scientist - Endometrial Biology
AI Summary
About us e184 is a biotechnology research company dedicated to overcoming the limits of human biology. One of our programs in reproductive technologies develops ectogenesis - the ability to support human development outside the body - to expand reproductive freedom and redefine what is possible in medicine.
About this role
About us
Role overview
What you'll do:
-
Develop endometrial model systems: Establish, optimize, and maintain in vitro endometrial models, including primary cells, organoids, or engineered tissue systems that recapitulate peri-implantation physiology.
-
Investigate implantation mechanisms: Design and execute experiments to identify molecular pathways regulating embryo attachment, invasion, decidualization, and early maternal-fetal signaling.
-
Characterize cellular and molecular responses: Apply imaging, histology, transcriptomics, and molecular assays to evaluate endometrial receptivity, cellular differentiation, and tissue remodeling.
-
Define embryo–endometrium interactions: Develop assays to study signaling and structural interactions during implantation and early development, integrating biological findings into experimental platform design.
-
Integrate multi-modal datasets: Analyze and interpret molecular, imaging, and functional data to generate mechanistic insight and guide experimental iteration.
-
Collaborate across disciplines: Partner with embryology, bioengineering, and computational teams to translate biological findings into design requirements for experimental systems supporting early development.
Core requirements:
-
PhD in Reproductive Biology, Developmental Biology, Cell Biology, Molecular Biology, or a related field, or 5+ years of relevant academic or industry experience.
-
Demonstrated expertise in endometrial biology, implantation biology, or maternal–fetal interface research.
-
Hands-on experience with mammalian cell culture and endometrial model systems (primary cells, stromal/epithelial co-culture, or organoids).
-
Strong understanding of decidualization, endometrial receptivity, and peri-implantation developmental processes.
-
Experience designing and executing mechanistic biological experiments independently.
-
Excellent organizational skills and attention to experimental rigor.
-
Ability to work collaboratively in an interdisciplinary research environment.
-
Enthusiasm for mission-driven science within a fast-paced startup setting.
You'll stand out with:
-
Experience working with human endometrial organoids or advanced in vitro implantation models.
-
Expertise in hormone-responsive endometrial systems and decidualization assays.
-
Hands-on histology experience, including tissue processing, sectioning, staining, and microscopy-based analysis.
-
Experience with transcriptomics, single-cell sequencing, or spatial omics approaches.
-
Background studying embryo–maternal signaling pathways or early placentation.
-
Experience integrating molecular datasets with functional developmental outcomes.
-
Prior startup, translational research, or early-stage technology development experience.
Why e184?
-
Unrivaled impact: Your work directly enables technology that transforms human fertility and reproductive medicine.
-
Full-spectrum growth: Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.
-
Best of both worlds: Experience the creative chaos of an early-stage startup with the stability of a well-capitalized company.
-
Elite collaboration: Work alongside a world-class team who are as driven as you are.
The perks:
-
Competitive salary + equity participation is considered
-
State-of-the-art facility in Portland metro area
-
Comprehensive Medical, Dental, Vision, and 401(k) with company match
-
20 days PTO + 11 paid holidays
Explore related jobs
More jobs at e184
Jobs in Portland
- Business Development RepresentativeCielo Projects · Portland, ME
Assistant Clinic ManagerSkinspirit · Portland
Specialty Sales Manager, Footwear - NAMARC'TERYX · Portland, OR- Front Office Associate Outpatient OncologyThe Oncology Institute of Hope and Innovation · Portland, Oregon
Withdrawal Management Program LeadRecovery Works NW · Portland, Oregon
Field InspectorQuiktrak · Portland, Oregon
