Scientist I (Contract), Analytical Development
AI Summary
Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked.
About this role
Join our Mission to Protect Humankind!
Summary:
We are seeking a highly motivated Scientist to join our analytical development team. In this role, you will play a key part in advancing complex vaccines by applying cutting-edge analytical techniques. This position offers the opportunity to take ownership of method development, contribute to impactful projects, and collaborate closely with cross-functional teams in a fast-paced, science-driven environment. The ideal candidate will embody and uphold our core values of rethinking convention, aiming high, leading with heart, and modeling excellence in all aspects of their work.
Essential Functions:
- Independently design and execute experiments to support analytical characterization of proteins, drug substances, and conjugates.
- Develop and optimize HPLC-based separation methods (e.g., AEX, SEC, SEC-MALS) to address complex analytical challenges.
- Design and implement mass spectrometry-based workflows for detailed molecular characterization.
- Analyze and interpret complex datasets and drive solutions forward.
- Maintain accurate and detailed records using an electronic laboratory notebook (ELN).
- Collaborate with cross-functional partners to support project goals and deliver high-quality analytical data.
- Communicate findings clearly through presentations and discussions, contributing to team learning and decision-making.
Requirements:
- PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 1-2 years; MS with 5+ years; BS with 8+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered.
- Proven experience in HPLC method development and optimization, particularly AEX, SEC, and SEC-MALS.
- Strong understanding of chromatographic principles and their application to biomolecular analysis.
- Working knowledge or experience with NMR spectroscopy is highly desirable.
- Hands-on experience with LC-MS, including peptide mapping and intact mass analysis.
- Familiarity with mass spectrometry platforms such as Orbitrap, Q-TOF, or triple quadrupole.
- Strong analytical thinking skills and the ability to troubleshoot complex problems independently.
- Detail-oriented with excellent documentation and organizational skills.
- Effective communicator and collaborative team player.
- Eager to learn, adaptable, and excited to contribute to a dynamic and innovative environment.
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.