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Capricor Therapeutics

Posted 1 month ago

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Scientist – Preclinical Team

San DiegoOn-siteFull-time

AI Summary

The Scientist will design, execute, and optimize in vivo and ex vivo preclinical studies, handle animals, run cell-based assays, and analyze data to advance Capricor's therapeutic programs in a regulated setting.

About this role

Capricor Therapeutics (NASDAQ: CAPR) is a biotechnology company dedicated to advancing transformative cell and exosome-based therapies for rare diseases. At the forefront of our innovation is Deramiocel (CAP-1002), our lead cell therapy in late-stage development for Duchenne muscular dystrophy. We are also harnessing our proprietary StealthX™ exosome platform to unlock new possibilities in targeted delivery and vaccinology. Every program reflects our commitment to pushing the boundaries of science and delivering life-changing treatments to patients and families who need them most.

We are seeking a Scientist to join our Pre-Clinical team to support the progression of our therapeutic programs through the design, execution, and optimization of in vivo research activities and preclinical studies. This role requires deep expertise in in vivo methodologies, strong technical skills, and the ability to perform complex operations in a regulated environment.

Responsibilities

  • Partner with the Principal Scientist and Director to provide preclinical expertise, including animal handling and study design.
  • Plan, execute, and analyze in vivo and ex vivo studies to support program objectives.
  • Perform cell-based assays and tissue analyses from in vivo studies; compile and report results.
  • Conduct survival surgeries and establish rodent models using aseptic techniques.
  • Develop, characterize, and implement new animal models to enhance pharmacology study effectiveness.
  • Maintain detailed, audit-ready documentation of all studies to ensure data integrity and traceability.
  • Optimize and implement best practices for in vivo research, including model selection, dosing strategies, and sample/data collection techniques.
  • Ensure compliance with regulatory guidelines and ethical standards for all preclinical activities.
  • Evaluate and integrate new technologies and platforms to improve study efficiency and quality.
  • Perform and interpret preclinical imaging studies (e.g., IVIS).
  • Contribute to a team culture that promotes continuous improvement, ownership, and inclusion.

    • Requirements

  • Ph.D. in a relevant scientific discipline with expertise in nonclinical operations within drug discovery and development.
  • Hands-on experience with cell biology techniques, including RNA/DNA extraction, PCR, Western blot, ELISA, and interventional assays for small molecules and biologics.

    • Preferred Qualifications

  • Experience across diverse therapeutic modalities (small molecules, biologics, nucleic acid therapeutics, gene therapy).
  • Familiarity with age-related disease models (inflammation, metabolic disorders, neurodegeneration, muscle atrophy, bone/joint deficits).
  • Experience with metabolic chambers, behavioral assays, and related data analysis.

    • Work Environment and Physical Demands

  • On-site laboratory environment with routine handling of animals and biological samples.
  • Prolonged periods of standing and performing surgical or technical procedures.
  • Ability to lift laboratory materials up to 20 pounds.

    • Skills

    Animal HandlingAseptic TechniquesCell BiologyData AnalysisDNA ExtractionDocumentation/audit-ready RecordsELISAInterventional AssaysIn-vivo Study DesignIVISModel DevelopmentPCRPharmacology Study DesignPreclinical ImagingRegulatory/complianceRNA ExtractionRodent ModelsStatistical AnalysisSurvival SurgeriesWestern Blot

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