Posted 3 months ago
Bench Scientist
Andover, MA, United StatesRemoteContract
AI Summary
A bench scientist will develop sensitive bioanalytical assays for anti-drug antibody characterization using mass spectrometry, execute sample prep and assays, and operate/maintain LC–MS/MS instrumentation with minimal supervision.
About this role
Bench Scientist
- A rare position is available for a bioanalytical scientist to join a state-of-the-art protein mass spectrometry laboratory lab in Pharmaceutical's Pharmacokinetics Dynamics and Metabolism department.
- The lab based role will focus on the development of a Client type of sensitive quantitative assay to characterize and quantify the effect of anti-drug antibodies against protein bio therapeutics in the context of unwanted immunogenicity.
- This position requires expertise in bioanalytical procedures including immunoanalytical workflows, solid background in protein biochemistry, and ideally expertise in triple quadrupole quantitative mass spectrometry.
- The candidate will participate in all phases of mass spec laboratory operations including the development of sample preparation methods, assay execution, instrument maintenance and data analysis/reporting. We are looking for a scientist passionate about learning and quickly applying new skills to the project needs.
Additional Skills:
- Apply existing protein quantitation workflows using bead and column based immunoaffinity enrichment including the use of liquid handling robotics.
- Run bioanalytical assays under minimal supervision; initiative in method development is expected.
- Independent daily operation, calibration, maintenance, and trouble shooting of multi-dimensional nanoflow liquid chromatography and nanospray triple quadrupole mass spectrometry instrumentation.
- Support analysis of quantitative LC-MS/MS data using relevant bioinformatics and quantitation software.
Additional Information
All your information will be kept confidential according to EEO guidelines.
Skills
BioinformaticsData AnalysisELISAImmunoassayLC-MS/MSLiquid Handling RoboticsMass SpectrometryNanoflow Liquid ChromatographyProtein BiochemistryTriple Quadrupole
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