Master Thesis – Impact of Capture Resin selection

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At Cytiva, we are developing chromatography resins for processing biopharmaceuticals, such as antibodies. The purification of antibodies is divided into a capture and one to two polishing steps. The capture step is affinity chromatography that aims to isolate the target antibody from the cell culture suspension. In the following polishing step(s), the aim is to remove process and product-related impurities such as aggregated, fragmented as well as residual host-cell proteins (HCPs) and DNA. The polishing resin can vary; however, ion-exchange or multimodal chromatography is commonly used. A variety of analytical techniques at each purification step are employed to ensure product purity and verify effective removal of impurities.

What you’ll do

Lab work aiming to evaluate separation performance of chromatography resins on Ab-related test material. This includes sample analysis using different detection methods, for example HPLC-SEC/RPC.

Who you are

• Master’s student in Science or Engineering with a focus on chemistry, biochemistry, or biotechnology.
• Eligible for master thesis work between January 2027 – June 2027.
• Background in chromatography is advantageous.
• You like to work independently and with a structured approach.

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