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Postdoctoral Research Associate - Immunology

MemphisOn-siteFull-time

AI Summary

Conducts postdoctoral research in immunology, investigating metabolic regulation of the immune system and its therapeutic impacts on cancer using CRISPR screening, single-cell transcriptomics, and other functional genomics tools.

About this role

Immunology postdoctoral positions are available in Dr. Hongbo Chi's laboratory in the Department of Immunology at St. Jude Children’s Research Hospital.

The Chi lab investigates immunobiology, immunometabolism and cancer immunology, by focusing on metabolic regulation of the immune system and the therapeutic impacts on cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in investigating the metabolic programs (e.g. amino acid and lipid metabolism), signaling pathways (e.g. mTOR and nutrient signaling), and systems-level regulatory networks that regulate basic T cell and dendritic cell biology and antitumor immunity. To this end, we apply interdisciplinary strategies by integrating immunological and genetic approaches with cutting-edge systems immunology and functional genomics tools, including in vivo CRISPR screening, single-cell transcriptomics, proteomics, metabolomics, and network reconstruction. Former trainees of the Chi lab have been principal investigators in multiple academic institutions. Please also see the following articles published over the past four years for additional information: Cell 187:205 (2024); Nature 624:154 (2023); Nature 620:200 (2023); Nature 623:1034 (2023); Nature Reviews Immunology 23:363 (2023); Nature 607:135 (2022); Nature 600:308 (2021); Nature 595:724 (2021); Nature 591:306 (2021); Cell 184:1245 (2021); and Nature Reviews Immunology 20:55 (2020);

St. Jude Children’s Research Hospital, ranked as a best children's hospital for pediatric cancer, offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salaries and excellent benefits, to postdoctoral fellows. To find out more about our benefits for postdocs, check out this link.

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St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Skills

Antitumor ImmunityCancer ImmunologyCRISPR ScreeningDendritic Cell BiologyImmunologyImmunometabolismMetabolomicsMTOR SignalingNetwork ReconstructionProteomicsSingle-cell TranscriptomicsT Cell Biology

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