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Posted 23 days ago

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Research Associate II, Production

San Mateo, CAOn-siteFull-time

AI Summary

Research Associate II, Production at BigHat Biosciences operates the company's high-throughput automated platform for antibody production and molecular characterization, performing DNA preparation, protein expression, characterization, and process optimization while maintaining documentation and collaborating on SOPs.

About this role

The role: BigHat Biosciences is seeking a self-motivated individual for a Research Associate II, Production role to power our high-throughput, automated platform for antibody production and deep molecular characterization.

*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.

Key Responsibilities

  • Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization.
  • Contribute to the scaling up of BigHat’s platform and production-grade data generation.
  • Support BigHat’s Platform Reagents & Assay Support (PRAS) function by contributing to in-house reagent manufacturing efforts.
  • Execute experiments to optimize the performance efficiency of BigHat’s platform.
  • Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.
  • Collaborate on the creation of laboratory standard operating procedures (SOPs) for sample processing.
  • Collaborate closely with BigHat team members to identify, design, and implement critical process and operational improvements to production workflows and laboratory systems.
  • Operate automated liquid handlers and analytical instruments to ensure all lab and platform operations run efficiently.

Skills, Knowledge & Expertise

  • BS in Biology or Chemistry, with 1+ year(s) of industry experience
  • Experience in process execution, laboratory method development, optimization, and troubleshooting.
  • Hands-on experience with, or interest in, automated liquid handlers (e.g. Hamilton, OpenTrons, Tecan, Agilent systems). Experience with LIMS is a nice-to-have.
  • Experience with molecular biology techniques and general lab practices.
  • Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment.
  • Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team.
  • Excellent record keeping abilities to document experimental work and analytical data.
  • Nice-to-haves include previous experience working with barcoding systems, inventory tracking, and experience with Google Workspace tools (Docs, Sheets, Slides, etc.)

Benefits

The salary estimated for this position is $85,000 - $100,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

Skills

Agilent SystemsAutomated Liquid HandlersBarcoding SystemsDNA PreparationGoogle WorkspaceHamiltonInventory TrackingLaboratory Method DevelopmentLIMSMolecular Biology TechniquesOpentronsProcess OptimizationProtein CharacterizationProtein ExpressionSOP CreationTecanTroubleshooting

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