Posted 1 month ago

Scientist I - Mass Spec Development (LC-MS/MS)

Kansas CityOn-site

AI Summary

Supports LC-MS/MS bioanalysis for drug discovery, preclinical, and clinical studies by preparing samples, performing analyses, processing data, and troubleshooting under senior scientist guidance.

About this role

Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Scientist at KCAS Bio is the role for you.

When you work as a Scientist in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by learning and applying your knowledge in bioanalytical and scientific principles to support study execution and development activities under the guidance of senior scientists. You will begin building your foundation in assessing data integrity and troubleshooting with support.

Our Mass Spec Bioanalysis Development team uses LC-MS/MS (Liquid Chromatography–Tandem Mass Spectrometry) techniques and sophisticated sample preparation methods to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including the bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.

In this role, we will rely on you to:

Execute assigned portions of studies including sample preparation (extractions, enrichments/affinity capture, digestions) and LC-MS/MS analysis under supervision

Support method development and qualification activities by following established protocols

Perform routine data processing and assist in preparing data summaries

Troubleshoot basic technical issues with guidance

Maintain accurate documentation in compliance with study protocols, SOPs & regulatory requirements

Ensure proper sample identification, handling, and tracking

Communicate progress and escalate issues to senior staff as needed

Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values

To qualify for this role, you will have:

Bachelor’s or master’s in chemistry, Biochemistry or chemical/biochemical engineering, or related field with 2+ years of experience with LC-MS/MS

Exposure to bioanalytical sample preparation and quantitative LC-MS/MS techniques (academic or industry)

Basic understanding of chromatographic principles and mass spectrometry

Experience with small molecule analysis; exposure to proteins and peptides is a plus

Familiarity with laboratory documentation and working in a structured or regulated environment is preferred

Skills

Affinity CaptureBioanalytical Sample PreparationChromatographic PrinciplesData ProcessingDigestionsExtractionsLC-MS/MSLiquid Chromatography–Tandem Mass SpectrometryMass SpectrometryMethod DevelopmentMethod QualificationPeptide AnalysisProtein AnalysisQuantitative LC-MS/MSSample PreparationSmall Molecule AnalysisSOPs

Scientist I - Mass Spec Development (LC-MS/MS)

About this role

In this role, we will rely on you to:

To qualify for this role, you will have:

Skills

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