Senior Principal Scientist, Medicinal Chemistry
AI Summary
A Senior Principal Scientist in Medicinal Chemistry independently drives lead optimization programs, designing novel molecules, interpreting SAR/DMPK/AI insights, and mentoring junior scientists while reporting to senior leadership.
About this role
Let’s build the future of medicine—together.
Senior Principal Scientist, Medicinal Chemistry
Hyderabad, India | Full-Time
As a Senior Principal Scientist, Medicinal Chemistry at Enveda, you will independently drive lead optimisation programmes — designing novel molecules, interpreting SAR, and shaping drug discovery strategy across multiple programmes. You will work at the intersection of synthetic chemistry, DMPK, biology, and AI-enabled design while mentoring the next generation of medicinal chemists. Reporting to the Director/AVP of Chemistry, your scientific ownership will directly advance our mission to deliver hope to patients everywhere.
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Independently design novel molecules, interpret SAR/SPR, and generate design hypotheses to drive lead optimisation programmes
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Integrate biology, DMPK, and AI insights into compound design; use AI-enabled molecular design tools to accelerate discovery
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Lead multiple discovery programmes with full scientific ownership and present strategy to cross-functional global teams
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Mentor junior scientists in medicinal chemistry thinking, scientific communication, and decision-making
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Ensure compliance with Enveda notebook SOPs, internal IP standards, and database requirements
WHAT WE'RE LOOKING FOR
PhD in Organic or Medicinal Chemistry from a leading research institution with 12-15 years of medicinal chemistry experience in CRO or integrated drug discovery
Demonstrated track record of independently driving lead optimisation and delivering preclinical candidates
Expert practical skills in synthetic organic chemistry, route design, and SAR/DMPK-informed decision-making
Strong rational drug design experience including novelty evaluation and IP awareness
Outstanding scientific presentation and communication skills; comfortable representing programmes to global teams
ABOUT ENVEDA
We recently raised $150M in a Series D, reached unicorn status, and advanced our first drug into Phase 2 trials. Forbes named us one of America's Best Startup Employers. Newsweek recognized us as a Top 100 Most Loved Workplace.
We're building something rare and we're just getting started!
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