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Janux Therapeutics

Posted 12 days ago

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Senior Research Associate, Analytical Development

San DiegoOn-siteFull-time

AI Summary

Designs and executes analytical experiments and sample analysis to support CMC, discovery, pre-clinical, and clinical development of immune oncology drug candidates.

About this role

Our Analytical Development team is growing and we’re seeking a Senior Research Associate to participate in designing and executing experiments, as well as perform sample analysis utilizing HPLC, CE-SDS, iCIEF, and plate-based assays. These activities will support CMC, discovery, pre-clinical, and clinical development of existing and new lead candidates. This position will directly support the discovery of next-generation immune oncology drugs. It is a hands-on position that requires effective communication and documentation of results to enable the advancement of novel research molecules toward development of clinical candidates, which will ultimately lead to late-stage development and commercialization. Ideal applicants will be agile and highly driven, collaborative, team-oriented, possess excellent communication and organization skills, and carry a strong commitment to excellence.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

  • Perform HPLC and UPLC assays with minimal supervision including SEC and RP.
  • Execute CE-SDS and iCIEF analysis for novel protein therapeutics and contribute to method optimization, qualification, and lifecycle management.
  • Perform ELISAs for potency assessment.
  • Perform DLS/SLS analysis using an UNcle instrument and generate datasets that will be used for formulation development studies.
  • Perform subvisible particulate matter analysis by HIAC.
  • Perform formulation development studies and execute clinical in-use stability studies, transfer formulation knowledge internally.
  • Design, conduct, analyze, interpret, and report laboratory experiments; summarize results for meetings and regulatory filings.
  • Write and manage SOP’s and test methods.
  • Manage and maintain required reagents, laboratory environment, and equipment needed to carry out assignments.
  • Draft development reports, method qualification protocols, and method qualification reports
  • Prepare presentations for team meetings.
  • Work closely with team leaders to complete highest priority work to reach goals and milestones.
  • Other duties as assigned.

    • REQUIRED SKILLS AND QUALIFICATIONS

  • Bachelor’s degree and 4-6 years of relevant industry experience or a master’s degree with 3-5 years of relevant industry experience.
  • Strong benchtop skills, experience with analysis of protein biologics and peptides.
  • Proficiency with HPLC and UPLC assays; at least 3 years of experience is required. SEC and RP are desired.
  • Experience with protein characterization techniques including CE-SDS, iCIEF, or related electrophoretic methods is preferred.
  • Experience performing ELISAs is desired but not necessary
  • Experience supporting analytical method qualification, comparability, stability, or formulation development studies is preferred.
  • Demonstrated ability to analyze complex datasets, identify trends, troubleshoot experiments, and communicate scientific conclusions effectively.
  • Ability to perform routine testing and to follow SOPs in a highly accurate and reproducible manner.
  • Desire and ability to learn new technologies and explore new approaches to innovate.
  • Training on project specific assays and ability to train others.
  • Proven experience with writing and maintaining SOPs.
  • Demonstrated ability to maintain accurate, complete, and contemporaneous experimental records in ELN systems in accordance with Good Documentation Practices (GDP).
  • Ability to work independently; anticipates and solves problems in a proactive fashion.
  • Must have excellent computer skills, and proficiency with Microsoft Excel and PowerPoint are required.
  • Good oral and written communication skills a must.
  • Excellent team player.

    • Skills

    CE-SDSDLSELISAELNExcelFormulation DevelopmentGood Documentation PracticesHIACHPLCIcIEFMethod QualificationPowerPointRPSECSLSSOP WritingStability StudiesUNcleUPLC

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