Senior Scientist II, Biomolecular Characterization

Key Responsibilities

• Individual contribution at the bench with strong cross-functional collaboration with scientists, ML/DS, and program teams.
• Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
• Design and perform epitope binning assays to cluster antibodies into functional families.
• Source, develop, and validate competitive binding/blocking assays to triage candidate antibodies.
• Collaborate closely with the BigHat science organization to accelerate hits from discovery through lead optimization and candidate nomination.
• Effectively synthesize and communicate results and research activity to key decision-makers and the broader BigHat team, as well as to external partners.

Skills, Knowledge & Expertise

• M.Sc/Ph.D. in molecular or cell biology, immunology, or related fields.
• 5+ years of advanced, independent research experience in an industry setting, including substantial experience with the Octet BLI and/or Biacore platforms.
• Practical and theoretical fluency with using various BLI sensor types for the determination of antibody-antigen binding kinetics and epitope binning.
• Deep technical knowledge regarding chip chemistries and characteristics for SPR measurements.
• Experience measuring binding interactions with recombinant soluble, transmembrane, and cell based antigens and a variety of antibody formats.
• Experience managing teams or demonstrated mentorship of junior scientists strongly preferred.
• Ability to manage and prioritize requests from cross-functional stakeholders.
• Strong data analysis and interpretation skills.
• Exceptional written, verbal, and visual communication skills.
• Ability to educate and build consensus among diverse stakeholders regarding scientific direction.
• Experience with lab automation is a plus.

Benefits