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Posted 15 months ago

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Research Associate – tRNA and mRNA Biology

Cambridge, MassachusettsOn-siteFull-time

AI Summary

Research Associate establishing cellular assays for tRNA therapeutic leads in neurobiology, designing and executing in vitro disease models in primary neurons, iPSCs, and rodent cell lines to characterize efficacy and safety.

About this role

Scismic is supporting the growth of a Cambridge, MA biotech startup that is pioneering mRNA-modulating therapies to cure a broad range of genetic diseases. The company is exploring the use of its novel platforms in neurological disorders, heart disease, and muscular dystrophies.

Position summary:
As an expert scientist in cellular neurobiology, you will be responsible for establishing cellular assays to demonstrate in vitro proof of concept for company tRNA therapeutic leads and characterize the cellular activity and downstream disease-relevant biology to help prioritize candidates for in vivo studies.

Key responsibilities for this position include:

  • Establish in vitro disease models in relevant cell types including primary neurons and glia isolated from transgenic animal models and patient-derived iPSC lines.
  • Design, troubleshoot, and execute cell-based assays in human and rodent cell lines to characterize the efficacy and safety of company's novel tRNA therapeutic leads.
  • Understand mechanism of action of lead candidates and establish assays and endpoints relevant to downstream target and disease biology. Conduct literature searches; communicate understanding in internal forums and with external collaborators and partners.

    • Minimum qualifications:

  • A BS/MS in Neurobiology, Molecular/Cellular Biology, physiology, or a related discipline.
  • Extensive hands-on experience with a variety of molecular, cellular and/or physiological techniques (isolating rodent neurons and establishing primary neuronal cultures, neurite outgrowth, qPCR, western blotting, microscopy, calcium imaging, synaptic imaging, multi-electrode arrays, human IPS/ES cell culture, etc).
  • Prior experience using AAV/lentivirus in primary or iPSC-derived neurons is highly desirable.
  • Ability to master new concepts and technologies quickly and run experiments independently.
  • Scientifically rigorous, highly organized, with excellent oral and written communication skills.
  • Ability to work independently as well as collaborate with colleagues and effectively prioritize and manage multiple tasks in a fluid, fast-paced work environment

    • Skills

    AAVCalcium ImagingCell CultureIPSCLentivirusMicroscopyMolecular BiologyMulti-electrode ArraysNeurophysiologyPrimary NeuronsQPCRSynaptic ImagingTRNA TherapeuticsWestern Blot

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