Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Drug Conjugation (ADC)

High Potent APIs (HPAPI):

• Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.

• Execute chemical reactions, work-ups, purification and related laboratory processes.

• Handle HPAPIs in accordance with applicable safety, containment and handling procedures.

• Maintain accurate laboratory records, experimental data and documentation.

• Support process development, optimization and troubleshooting activities.

• Perform analytical sample preparation and coordinate with analytical teams as required.

• Follow established GMP, EHS and laboratory safety requirements.

• Support investigation and resolution of laboratory/process-related issues.

• Where required, support chemistry activities related to ADC and highly potent payloads.

• Work effectively with cross-functional teams including analytical and other chemistry groups.

Organic Chemist:

• Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance

• Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography

• Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations

• Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately
  

Peptide Chemist:

• Hands-on expertise in solid-phase and solution-phase peptide synthesis using automated synthesisers like Syro and Liberty CEM

• Strong experience in peptide purification, characterisation, and analytical techniques, including HPLC, LCMS, and MS

• Capable of independently handling medium- to large-scale peptide synthesis (1 g to 1 kg scale) with troubleshooting abilities

• Skilled in laboratory operations, equipment maintenance, SHE compliance, literature review, and accurate experimental documentation

Scaleup Chemist:

• Experience in process R&D, scale-up synthesis, and purification from gm to kg scale

• Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities

• Proficient in 1H NMR, HPLC, and LCMS interpretation

• Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

• Synthesis and purification of complex antibody drug conjugate (ADC) molecules

• Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs

• Synthesis of highly potent drug molecules – payloads

• Purification of complex and large molecules by flash column and HPLC

• Handling various type chemistry with different payloads

• Interpretation and characterisation of higher molecular weight compounds

Requirements

Principal Scientist;

• PhD/MSc in Organic Chemistry / Medicinal Chemistry or related field.

• Strong experience in CRO/CDMO research environment.

• Proven team management experience with exposure to handling multiple projects.

• Excellent communication and client-facing skills.

• Ability to drive productivity, scientific excellence, and team development.

Organic Chemist:

• Master’s in Organic Chemistry with 1-3 years of experience in the CRO Industry
  Strong organisational, project management and problem-solving skills with impeccable multi-tasking abilities.

• Proactive, highly motivated with a "can do" attitude

• Exceptional interpersonal skills.

Peptide/Scaleup/Antibody Drug Conjugation (ADC) Chemist:

• Master’s in Organic Chemistry with a minimum of 2 years and a maximum of 6 years of experience in the CRO/API Industry

• Adherence to safe practices and procedures

• Contribution to the development of safety protocols and systems

• Must be able to prioritize and organize work responsibilities in order to meet deadlines