Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Scientist at KCAS Bio is the role for you.
When you work as a Scientist III in the Flow Cytometry group at KCAS, you get to further our mission by applying your knowledge in bioanalytical and scientific principles to independently execute studies and support the development, qualification, and validation of flow cytometry and cell-based assays. You will utilize your strong scientific foundation to assess assay performance, interpret data, troubleshoot complex technical issues, and ensure the integrity and quality of study results.
Our Flow Cytometry team utilizes advanced instrumentation and analytical techniques to support bioanalytical testing in drug discovery, preclinical, and clinical studies, including immunophenotyping, cell-based assays, and biomarker analysis in biological matrices.
In this role, we will rely on you to:
Independently execute and support flow cytometry studies from study setup through data generation, analysis, and reporting
Develop, optimize, qualify, validate, and transfer flow cytometry methods in support of preclinical and clinical studies
Design and optimize multiparametric flow cytometry panels, including selection and evaluation of antibody clones, fluorochromes, titrations, controls, sample matrices, and gating strategies
Perform flow cytometry sample preparation, staining, data acquisition, analysis, and interpretation
Operate conventional and spectral flow cytometry instrumentation, including platforms such as Cytek Aurora and BD flow cytometers
Develop and optimize assays utilizing biological matrices such as whole blood, fresh or cryopreserved PBMCs, bone marrow, tissue, and cell lines
Analyze and interpret complex flow cytometry data and prepare data summaries and presentations for internal and client reviews
Evaluate assay performance characteristics including precision, accuracy, sensitivity, selectivity, stability, robustness, linearity, and other applicable parameters
Troubleshoot complex assay, sample, reagent, instrumentation, and data analysis issues and develop scientifically sound solutions
Apply knowledge of immunology and cell biology to immunophenotyping, biomarker, and functional cellular assay applications
Support study activities involving applications such as immune profiling, receptor occupancy, target engagement, intracellular marker analysis, proliferation, and other functional cellular endpoints as applicable
Ensure proper sample identification, handling, processing, storage, and tracking throughout study execution
Maintain accurate and complete documentation in accordance with study protocols, SOPs, and applicable regulatory and quality requirements
Review and interpret scientific data to identify trends, inconsistencies, and potential risks to study execution or data quality
Prepare and review protocols, study documentation, data summaries, and reports
Communicate scientific findings, study progress, technical challenges, and recommendations to project teams, management, and clients as appropriate
Provide technical guidance and training to less experienced scientific staff
Collaborate with Quality Assurance and other cross-functional teams to resolve study or data-related issues
Maintain knowledge of current scientific, technological, and regulatory developments relevant to flow cytometry
Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values
To qualify specifically for this role, you will have:
Bachelor’s degree in Biology, Immunology, Cell Biology, or related scientific field
At least 4 years of relevant laboratory experience in flow cytometry, immunology, cell biology, bioanalysis, or a related area
Strong hands-on experience with flow cytometry techniques and instrumentation
Experience with spectral and/or conventional flow cytometry
Experience with multiparametric flow cytometry, including panel design and optimization, staining, controls, data acquisition, gating strategies, and data interpretation
Experience developing, optimizing, qualifying, validating, and/or transferring flow cytometry methods
Experience working with biological matrices such as whole blood and PBMCs
Strong understanding of immunology, cell biology, immunophenotyping, and cell-based assay principles
Experience troubleshooting complex flow cytometry assays, reagents, instrumentation, and data quality issues
Experience with flow cytometry data analysis software
Strong understanding of assay performance characteristics and fit-for-purpose method development and validation
Experience working within SOP-driven and regulated laboratory environments
Strong technical documentation skills with a commitment to data integrity and scientific quality
Strong written and verbal communication skills with the ability to communicate scientific information effectively
Ability to work independently while collaborating effectively with scientific and cross-functional teams
Ability to provide technical guidance and training to less experienced scientists
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