Senior Research Associate & Group Leader - DMPK

Senior Research Associate - DMPK

• Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays

• Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)

• Support development and validation of new ADME assays to expand the group’s scientific capabilities

• Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)

• Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators

• Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable

• Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions

• Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams

• Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics

Group Leader - DMPK

• Lead, mentor, and develop a team of scientists engaged in In-Vitro ADME/DMPK studies.

• Oversee the design, execution, analysis, and interpretation of In-Vitro ADME studies, including metabolism, transporter, and drug-drug interaction assessments.

• Manage external CRO partnerships for In-Vivo PK studies, ensuring timely execution, data quality, and delivery.

• Provide scientific guidance and DMPK strategies to support drug discovery and development projects.

• Analyze and interpret study data, prepare technical reports, and present findings to internal and external stakeholders.

• Serve as the primary scientific point of contact for clients, ensuring effective communication and project delivery.

• Support proposal preparation, project scoping, contract review, and project onboarding activities.

• Manage study budgets, resource allocation, and operational efficiency.

• Drive continuous improvement initiatives and implement best practices across DMPK operations.

• Collaborate closely with cross-functional teams to integrate ADME/DMPK data into project decisions.

• Prepare and present monthly MIS reports, including project status, resource utilization, risks, and key performance metrics.

Requirements

Senior Research Associate - DMPK

• Master's in Lifescience with 4-5 years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.

• Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles

• Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments

• Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding

• Ability to troubleshoot experimental challenges and apply sound scientific judgment

• Self-driven and capable of managing multiple tasks while working within demanding project timelines

• Strong attention to detail and commitment to maintaining high scientific and data quality standards

• Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams

• Strong communication skills for interacting with internal teams, collaborators, and stakeholders

• Highly organised with the ability to function effectively in a fast-paced research environment

• Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs

• A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h

Group Leader - ADME/DMPK

• Ph.D. in Pharmaceutical Sciences, Pharmacology, or a related Life Sciences discipline.

• 10–15 years of relevant experience in DMPK, In-Vitro ADME, and Pharmacokinetic sciences within pharmaceutical, biotechnology, or CRO organizations.

• Proven experience in leading scientific teams and managing complex research projects.

• Strong expertise in In-Vitro ADME studies and interpretation of DMPK data.

• Experience managing CRO collaborations and outsourced In-Vivo PK studies.

• Excellent leadership, project management, communication, and stakeholder management skills.

• Strong analytical and problem-solving capabilities with a client-focused approach.

• Ability to communicate complex scientific concepts effectively to diverse audiences.