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Posted 10 days ago

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Senior Scientist, Translational Research

Watertown, MARemote

AI Summary

Lead image-based biomarker analyses and preclinical experimental design using HALO for immunology and inflammation programs; manage CROs and external collaborators to advance therapeutic discovery.

About this role

COMPANY INTRODUCTION
Triveni Bio is breaking new ground in the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine. We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) to directly impact skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders. In all the work we do, we adhere to our core values: patient impact, bold and rigorous science, open collaboration, kindness & respect.

SUMMARY

Triveni Bio is seeking a highly motivated and experienced Scientist to join our Biology and Translational Research team. In this role, you will lead image-based biomarker analyses and drive the experimental design and execution of cell-based and ex vivo preclinical models. This is an exciting opportunity to shape the scientific biomarker strategy across multiple indications, advancing therapeutics that target novel disease pathways. If you are passionate about therapeutic discovery and possess extensive expertise in image analysis, we want to hear from you.

RESPONSIBILITIES

  • Lead image-based biomarker analyses using HALO to support biomarker analyses
  • Design and execute experimental cell-based and ex vivo preclinical models
  • Oversee external research activities, to meet timelines, deliverables, and data quality with Contract Research Organizations (CROs) or academic collaborators
  • EXPERIENCE & QUALIFICATIONS

  • Ph.D. in molecular biology or related a related discipline with 5+ years of experience within the pharmaceutical or biotechnology sectors.
  • Extensive, hands-on expertise in image analysis utilizing HALO.
  • Solid background in Immunology and Inflammation indications, with a strong preference for specific experience in atopic dermatitis.
  • Familiarity or expertise in mechanistic cell-based and cell-free assays to investigate type 2 immunity, including immune cells, mast cells, IgE biology, cytokine modulation, and other relevant pharmacodynamic readouts.
  • Proven track record of effectively managing Contract Research Organizations (CROs), external vendors, and academic collaborators.
  • Skills

    Atopic DermatitisCell-based AssaysCRO ManagementEx Vivo ModelsHaloImage AnalysisImmunologyInflammationMendelian GeneticsMolecular Biology

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