Posted 2 months ago
Director/Senior Director, In Vivo Pharmacology
AI Summary
Director/Senior Director of In Vivo Pharmacology leading strategy, study design, execution, and interpretation of in vivo pharmacology studies for oncology programs; mentors scientists and shapes pharmacology function.
About this role
The Opportunity
Rezo is seeking an experienced Director/Senior Director of In Vivo Pharmacology to lead the strategy, design, execution, and interpretation of in vivo pharmacology studies across our oncology portfolio.
The successful candidate will bring deep expertise in oncology models, PK/PD-driven study design, translational pharmacology, and cross-functional drug discovery. They will work closely with biology, medicinal chemistry, DMPK, and external CRO partners to generate robust, decision-driving in vivo data packages.
This is an opportunity to build and shape the in vivo pharmacology function at a growing oncology biotech, with direct impact on program strategy and portfolio progression.
Key Responsibilities:
Qualifications:
- PhD in pharmacology, cancer biology, molecular biology, physiology, translational medicine, or a related discipline, with typically 10+ years of relevant industry experience in oncology drug discovery or translational pharmacology.
- Deep expertise in in vivo pharmacology for small-molecule oncology drug discovery.
- Strong track record designing and interpreting efficacy, PK/PD, dose-response, dose-scheduling, and mechanism-of-action studies in oncology models.
- Hands-on experience with rodent oncology models and a strong understanding of the strengths, limitations, and translational relevance of CDX, PDX, and syngeneic models.
- Demonstrated ability to integrate in vivo pharmacology with medicinal chemistry, DMPK, and biomarker strategy.
- Experience advancing programs from discovery through development candidate nomination.
- Strong CRO management experience, including protocol design, study oversight, data QC, troubleshooting, and vendor accountability.
- Ability to operate at both strategic and detailed execution levels in a small-company setting.
